(1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-oxo-2-phenylpropanoate
8-isopropyl-8-azabicyclo[3.2.1]oct-3-yl endo-(±)-formylphenylacetate
CAS: 22235-74-1
Molecular Formula: C19H25NO3
(1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-oxo-2-phenylpropanoate - Names and Identifiers
(1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-oxo-2-phenylpropanoate - Physico-chemical Properties
| Molecular Formula | C19H25NO3 |
| Molar Mass | 315.41 |
| Density | 1.14±0.1 g/cm3(Predicted) |
| Melting Point | 203 °C |
| Boling Point | 421.5±45.0 °C(Predicted) |
| pKa | 6.37±0.29(Predicted) |
| Physical and Chemical Properties | Light yellow crystals. Melting point 154-160 ℃. |
(1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-oxo-2-phenylpropanoate - References
| Use | an intermediate of isopropylatropine. |
| production method | 2, 5-dimethoxytetrahydrofuran is heated with hydrochloric acid to open the ring to form butanedial, which is then mixed with isopropylamine, acetone dicarboxylic acid addition, condensation and decarboxylation, N-isopropyl nortropone. The latter was hydrogenated by the catalysis of nickel bromide to obtain N-isopropyl desmethylopetriol, and then refluxed with methyl 2-formylphenylacetate in toluene, and transesterified to obtain the product. |
Last Update：2024-04-09 21:04:16
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